time is a wibbly wobbly timey wimey stuff

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Wed, 22 May 2013 15:39:49 -0700

I don’t know where I am. It’s like I’m breaking into a million...

Wed, 22 May 2013 15:39:08 -0700

I don’t know where I am. It’s like I’m breaking into a million pieces and there’s only one thing I remember: I have to save the Doctor. He always looks different…I always know it’s him. Sometimes, I think I’m everywhere at once, running every second just to find him. Just to save him. But he never hears me—almost never. I blew into this world on a leaf, I’m still blowing. I don’t think I’ll ever land. I’m Clara Oswald. I’m the Impossible Girl. I was born to save the Doctor.

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Wed, 22 May 2013 15:19:42 -0700

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Wed, 22 May 2013 15:19:34 -0700

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Wed, 22 May 2013 14:52:14 -0700

thefrogman: Saturday Morning Breakfast Cereal by Zach Wiener...

Wed, 22 May 2013 14:49:00 -0700

thefrogman:

Saturday Morning Breakfast Cereal by Zach Wiener [website]

[h/t: bluedogeyes]

tastefullyoffensive: domics: Right after we get froyo.

Wed, 22 May 2013 14:31:46 -0700

tastefullyoffensive:

domics: Right after we get froyo.

poopinthespeedforce: this is amazing a japanese superhero who...

Wed, 22 May 2013 14:27:35 -0700

poopinthespeedforce:

this is amazing

a japanese superhero who actually resembles a japanese superhero instead of looking exactly like a justice league member (but asian).

this almost makes up for how shitty things like the super young team and the great ten were in the past.

neurosciencestuff: Reducing caloric intake delays nerve cell...

Wed, 22 May 2013 14:26:54 -0700

neurosciencestuff:

Reducing caloric intake delays nerve cell loss

Activating an enzyme known to play a role in the anti-aging benefits of calorie restriction delays the loss of brain cells and preserves cognitive function in mice, according to a study published in the May 22 issue of The Journal of Neuroscience. The findings could one day guide researchers to discover drug alternatives that slow the progress of age-associated impairments in the brain.

Previous studies have shown that reducing calorie consumption extends the lifespan of a variety of species and decreases the brain changes that often accompany aging and neurodegenerative diseases such as Alzheimer’s. There is also evidence that caloric restriction activates an enzyme called Sirtuin 1 (SIRT1), which studies suggest offers some protection against age-associated impairments in the brain.

In the current study, Li-Huei Tsai — director of the Picower Institute for Learning and Memory and Picower Professor of Neuroscience at MIT — along with postdoc Johannes Gräff and others at MIT tested whether reducing caloric intake would delay the onset of nerve cell loss that is common in neurodegenerative disease, and if so, whether SIRT1 activation was driving this effect. The group not only confirmed that caloric restriction delays nerve cell loss, but also found that a drug that activates SIRT1 produces the same effects.

“There has been great interest in finding compounds that mimic the benefits of caloric restriction that could be used to delay the onset of age-associated problems and/or diseases,” says Dr. Luigi Puglielli, who studies aging at the University of Wisconsin, Madison, and was not involved in this study. “If proven safe for humans, this study suggests such a drug could be used as a preventive tool to delay the onset of neurodegeneration associated with several diseases that affect the aging brain.”

In the study, Tsai’s team first decreased the normal diets of mice genetically engineered to rapidly undergo changes in the brain associated with neurodegeneration by 30 percent. Following three months on the diet, the mice completed several learning and memory tests. “We not only observed a delay in the onset of neurodegeneration in the calorie-restricted mice, but the animals were spared the learning and memory deficits of mice that did not consume reduced-calorie diets,” Tsai says.

Curious if they could recreate the benefits of caloric restriction without changing the animals’ diets, the scientists gave a separate group of mice a drug that activates SIRT1. Similar to what the researchers found in the mice exposed to reduced-calorie diets, the mice that received the drug had less cell loss and better cellular connectivity than the mice that did not receive the drug. Additionally, the mice that received the drug treatment performed as well as normal mice in learning and memory tests.

“The question now is whether this type of treatment will work in other animal models, whether it’s safe for use over time, and whether it only temporarily slows down the progression of neurodegeneration or stops it altogether,” Tsai says.

defranco: excitedtard: (X) I make weird faces. I can’t help...

Wed, 22 May 2013 14:15:32 -0700

defranco:

excitedtard:

(X)

I make weird faces. I can’t help it. I’m Italian. We are physically unable to control our arms and faces.

if yahoo buys tumblr (ALL TRUE!!):

Wed, 22 May 2013 14:14:52 -0700

daftpostpunk:

post limit gets changed to 150 posts a day

you can’t google tumblr anymore you must yahoo it

no more selfies allowed

blogs with less than 300 followers will be deleted

heroin will be legalized

george bush will become president again

stock market will crash

korea will blow the US up

world war 3

cuteguyss: Danny

Wed, 22 May 2013 14:11:20 -0700

cuteguyss:

Danny

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Wed, 22 May 2013 14:08:49 -0700

detention: katwii: lovemetoinfinity: sexting-inchurch: the...

Wed, 22 May 2013 14:08:31 -0700

detention:

katwii:

lovemetoinfinity:

sexting-inchurch:

the way he looks at her…….

i wish someone would look at me that way

he gives me that stare, it makes me feel lovely

perf

matthulksmash: hallowbedeathly: cataclysmmagazine: Scenery -...

Wed, 22 May 2013 14:07:13 -0700

matthulksmash:

hallowbedeathly:

cataclysmmagazine:

Scenery - The Great Gatsby (2013)

Beautiful movie is beautiful.

If Luhrmann knows how to do one thing, it’s make GORGEOUS scenery.

lilarmadillo: I need this in my life.

Wed, 22 May 2013 14:04:55 -0700

lilarmadillo:

I need this in my life.

yellowfur: feels like I havent drawn for ages have some chubby...

Wed, 22 May 2013 14:00:30 -0700

yellowfur:

feels like I havent drawn for ages

have some chubby raichu

liberalsarecool: The GOP hates students, loves their debt...

Wed, 22 May 2013 13:59:29 -0700

liberalsarecool:

The GOP hates students, loves their debt payments.

iwishenglandwouldgetaheadache: rosalarian: appleznbananaz: add...

Wed, 22 May 2013 01:56:01 -0700

iwishenglandwouldgetaheadache:

rosalarian:

appleznbananaz:

addisuns:

if the villains won

This is a terrible post.

Creepily wonderful

The painting of Gaston and Belle in the background is what got me.

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Wed, 22 May 2013 01:54:28 -0700